![]() ![]() The TM-align is a structural alignment programįor comparing two proteins whose sequences can be different. It is usually NOT applied to compare two proteins of different sequences. What is the difference between TM-score and TM-align?īased on their given residue equivalency (i.e., based on the residue index in the PDB file).Click here to view Frequently Asked Questions on TM-score.To view a brief instruction on how to run TM-score program. How to calculate TM-score if your model and native structures are mislabelled?.Click to download a java version of the TM-score program.Click RMSD.f to download the source code for calculating RMSD only.Click TMscore_subroutine.f to download the subroutine code that can quickly calculate TM-score and be conveniently included as a subroutine in any Fortran program.Higher speed to run the program (See above step). The TM-score source code and compile it on your machine, which gives you Nevertheless, it is recommended to download >g77 -static -O3 -lm -o TMscore TMscore.fĬlick TMscore_cpp to download the executable programįor Linux system. >gfortran -static -O3 -ffast-math -lm -o TMscore TMscore.f To download the newest version of the TM-score source code in Fortran77. >g++ -static -O3 -ffast-math -lm -o TMscore TMscore.cpp Such as Mac, which does not support static build): (you can ignore the '-static' option for some machines, You can compile the program in your Linux computer by ![]() To download the newest version of the TM-score source code in C++. Input Email: (optional, where results will be sent to).Merge all chains and compare them as monomers). These are complex structures (server will Input Structure 2, Experimental structure in PDB format (mandatory):.Please copy and paste your structure file here. TM-score on-line ( view an example of output) Please read " Problem and Solution", if you have problem on how to calculate Higher than 0.5 assume generally the same fold in SCOP/CATH. Scores below 0.17 correspond to randomly chosen unrelated proteins whereas structures with a score TM-score has the value in (0,1], where 1 indicates a perfect match between two structures.įollowing strict statistics of structures in the PDB, (2) TM-score introduces a length-dependent scale to normalize theĭistance errors and makes the magnitude of TM-score length-independent Similarity than to the local structural variations (1) TM-score weights smaller distance errors stronger than larger distanceĮrrors and makes the score value more sensitive to the global fold It is designed to solve two major problems in traditional metrics such as TM-score is a metric for assessing the topological similarity of protein structures. ![]()
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